He married Delila Smith on October 10, 1839 in Washington County, Tennessee. Her parents were Turner Smith and Mary A. Ruble. Delila was born on September 2, 1811 in Washington County, Tennessee.
John and Delila's children included:
William Hart Humphreys (often confused with William Hyder Humphreys, Jr.),
Julia Adelade Humphreys Maloney (1842, married Barney Maloney),
John S. Humphreys (1844),
Martha Ellen Humphreys (1847, married William Morris - may be grandson of Robert Morris),
Frances Jesse Marion Humphreys (1849),
Sarah Margaret Humphreys Range (1852, married James W. Range),
Laura Lorina Humphreys Purkey (1854, married Michael Jonathan Purkey), and
Mary A. Humphreys (1857).
In 1806, John Humphreys, along with John Johnson, bought 415 acres on the Doe River from Dillon Blevins. The Doe River is a tributary of the Watauga River.
In 1830 his father stated in his Revolutionary War pension hearing that his son, John Humphreys lived in Carter County, Tennessee. The census records show the John Humphreys household consisted of:
a man and two women born between 1790 and 1800
and nine children.
At the time of the 1850 census, they were in subdivision 4 of Washington County, Tennessee. The household consisted of John age 56, Julia age 38, Wm. H. age 9, Julia age 7, John S. age 6, Frances M. age 1, and Martha E. age 3.
In 1860 they were in district 8, post office Jonesborough, Tennessee. The household consisted of John age 65, Delila age 48, William H. age 19, John S. age 16, Jesse M. age 11, Sarah age 8, Laura age 6, and Mary A age 3.
John died on September 22, 1876 and Delila followed on November 30, 1877. They are buried together in the Babb/Smith Cemetery in Jonesborough, Tennessee.
